Correct Coding of Molecular Testing Panels (Revised)
March 6, 2024Effective 1/1/2024, DNA analysis or DNA and RNA analysis using a single combined method, are to be reported with code 81445,81450,81455, 81457, 81458, 81459, 81462, 81463 or 81464. RNA analysis performed using a separate method, is reported with code 81449, 81451 or 81456. When evaluation for TMB and/or MSI is performed as part of the same test for somatic alterations in neoplasms, report using code 81458 or 81459. When a GSP is performed on cell-free nucleic acid (eg, plasma), sometimes referred to as a liquid biopsy, report using code 81462, 81463 or 81464.
When a panel with greater than one or less than five genes is ordered, use the corresponding existing panel CPT code or CPT code 81479 if none exists.